The only way to kill you permanently is to destroy you entirely. Just because he has a healing factor doesn't mean he can't lose; it simply means his opponent has to get creative to find a way to keep him down. Even if Bane can't punch deadpool out he can still put him into a submission hold or something along those lines which would count as incapacitation. During that comic's first arc, "If Looks Could Kill," the titular heroes are infected by the Facade Virus, a disease that allows victims to change their faces. Marvel Comics has announced, via Nerdist, that they will be killing Deadpool in April's Deadpool #250, which will be the final issue of his ongoing series. #5 Deadpool: If you guys are wondering how Deadpool could defeat the man of steel, severe even we don’t know the answer. If anyone can kill off Deadpool it's marvel. Well now it's payback time, because this time around, the heroes are beating down Deadpool. "Dreadpool," the evil Deadpool from Deadpool Kills the Marvel Universe, is searching for new universes to depopulate and stumbles into the Post-Crisis DC Universe.. Dreadpool: has a healing factor that's cranked up beyond even Deadpool's typical standards. Even Jesus can be seen as a kind of outlaw, in that He came into conflict with a corrupt legal system. Deadpool: You are an interesting problem, Doomsday. Only Doomsday can kill Superman! We've already talked about the superheroes Deadpool has beaten, many of whom were courtesy of Deadpool's killing spree against the Marvel universe. But traditionally even Batman was still a hero who didn’t kill indiscriminately. Likewise, when it comes to comic books, there always has been a range of superheroes. Marvel have just announced "The Death of Deadpool". The only thing that has ever killed Superman. Not only that, but every time somebody kills you, you just come back immune to whatever killed you before. ... Now, Deadpool can get drunk. One of the main reasons that the Merc with a Mouth is so lethal is because he’s dedicated to killing his targets. First of all one must have an understanding that both are immortal and equally badass in their own rights.Both are antiheroes,bounty hunters and mercenaries (not lobo),both are skilled in weapon usage and hand to hand combat blah blah…. Where Superman refuses to kill, that is all Deadpool … Deadpool's morality has shifted over the years for Deadpool, with the Merc with a Mouth transforming from a villain to a hero over the years. I just don't think he has the intelligence to lay a good enough trap to beat and or kill Superman. Supes looks at Deadpool and his Swords or Guns chuckles a bit then throws him into space. This includes some notoriously hard to kill characters like the Hulk, Wolverine, Luke Cage, and the rest of the Avengers and the X-Men. 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